反应详情

Iron powder (3 g), water (20 mL) and concentrated hydrochloric acid (3 mL) were mixed, and 2-(methylthio)-5-nitropyridine (2 g, 12 mmol) was added portionwise. After reflux reaction for 2 hours, the reaction mixture was basified with 1N sodium hydroxide and extracted with 20 mL ethyl acetate for three times. The combined organic phase was dried with anhydrous sodium sulfate, filtered and concentrated to yield the target compound (1.54 g, 11 mmol).

1. temperatureAfter reflux
2. customreaction for 2 hours
3. extractionextracted with 20 mL ethyl acetate for three times
4. dry with materialThe combined organic phase was dried with anhydrous sodium sulfate
5. filtrationfiltered
6. concentrationconcentrated