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HRID1523707

反应详情

EQUATION

反应方程式

HRID 1523707 的结构方程式

REACTANTS

反应物

3
结构：[Br-].[Li+]
HCID82050

Lithium bromide

BrLi

结构：O=C1c2ccccc2C(=O)N1C[C@H]1CO1
HCID719412

2-{[(2S)-Oxiran-2-yl]methyl}-1H-isoindole-1,3(2H)-dione

C11H9NO3

结构：O=C=Nc1ccc(N2CCOCC2=O)cc1
HCID53341421

4-(4-Isocyanatophenyl)morpholin-3-one

C11H10N2O3

PRODUCTS

生成物

1
结构：O=C1c2ccccc2C(=O)N1C[C@H]1CN(c2ccc(N3CCOCC3=O)cc2)C(=O)O1
HCID11690317

2-({(5S)-2-Oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1,3(2H)-dione

C22H19N3O6

收率 91.75%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

CONDITIONS

反应条件

温度
140 °C

PROCEDURE

实验过程

(S)-2-(oxiran-2-ylmethyl)isoindoline-1,3-dione (3.87 g, 19.06 mmol, 1.1 eq.) and 4-(4-isocyanatophenyl)morpholin-3-one (3.77 g, 17.29 mmol) were dissolved in N,N-dimethylformamide (70 mL) respectively and heated to 140° C. Then lithium bromide (0.15 g, 1.74 mmol) was added, the mixture was reacted for 4 h, white solid was obtained by filtration (6.68 g, yield: 91.75%).

WORKUP

后处理

  1. customthe mixture was reacted for 4 h
  2. customwhite solid was obtained by filtration (6.68 g, yield: 91.75%)