反应详情

A mixture of 3-bromopyridine-2-thiol (0.30 g, 1.6 mmol), tert-butyl 3-bromopyrrolidine-1-carboxylate (0.79 g, 3.2 mmol) and K2CO3 (438 mg, 3.20 mmol) in DMF (12 mL) was stirred at rt for 4 h. The reaction mixture was concentrated to dryness and the residue subjected to FCC purification to give partially purified title compound (1.05 g, 63% purity).

1. concentrationThe reaction mixture was concentrated to dryness
2. customthe residue subjected to FCC purification
3. customto give partially
4. custompurified title compound (1.05 g, 63% purity)