反应详情

Chloroacetyl chloride (0.37 ml, 4.6 mmol) was added to a solution of indoline (0.47 ml, 4.19 mmol) and triethylamine (TEA; 0.70 ml, 5.03 mmol) in dichloromethane (DCM; 15 ml). The mixture was stirred for 3 hrs at room temperature (RT) and then quenched with water (5 ml). The phases were separated and the aqueous layer was extracted with DCM (3×5 ml). The combined organic layers were dried over MgSO4 and concentrated to a dark brown residue, 1 g (quantitative), which was used for the next step without further purification.

1. customquenched with water (5 ml)
2. customThe phases were separated
3. extractionthe aqueous layer was extracted with DCM (3×5 ml)
4. dry with materialThe combined organic layers were dried over MgSO4
5. concentrationconcentrated to a dark brown residue, 1 g (quantitative), which
6. customwas used for the next step without further purification