反应详情

Essentially the same procedure was used to make compound 24s as was used for compound 18s (Example 16), with compound 48 (Example 7; 55 mg, 0.2 mmol), 3-methoxyphenol (0.032 ml, 0.3 mmol), triphenylphosphine (78 mg, 0.3 mmol), DEAD (0.05 ml, 0.3 mmol), and THF (1 ml). The crude residue was purified twice by flash column chromatography (silica, DCM/MeOH 1:0 to 8:2) to afford the title compound as a colourless oil (60 mg; 78%). Analyses were performed on the free base, and the free base was converted to the HCl salt for testing.

1. customThe crude residue was purified twice by flash column chromatography (silica, DCM/MeOH 1:0 to 8:2)