Potassium Cyanide → HCID 58136957, compound

HRID 1524490Notes

Reaction equation

HRID 1524490 reaction equation
CS([C:5]1[C:6]([CH3:16])=[C:7]([CH3:15])[C:8]2[N:9]([C:11]([NH2:14])=[N:12][N:13]=2)[N:10]=1)(=O)=O.[C-:17]#[N:18].[K+]>CN(C=O)C>[NH2:14][C:11]1[N:9]2[N:10]=[C:5]([C:17]#[N:18])[C:6]([CH3:16])=[C:7]([CH3:15])[C:8]2=[N:13][N:12]=1

Participants

4

Reactant 2

HCID 9032Potassium CyanideHCID 58136894HCID 58136894, compound

Product 1

HCID 58136957HCID 58136957, compoundYield 71.8%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
100 °C

Procedure

6-Methanesulfonyl-7,8-dimethyl-[1,2,4]triazolo[4,3-b]pyridazin-3-ylamine (W1.130; 1.0 g) was dissolved in DMF (30 ml) and admixed with potassium cyanide (405 mg). After stirring at 100° C. for 1 h, the mixture was dried. The residue was stirred in EA and chromatographed using a short silica gel column with EA. Fractions concentrated by rotary evaporation. 560 mg of the title compound were obtained.

Workup

  1. customthe mixture was dried
  2. stirringThe residue was stirred in EA
  3. customchromatographed
  4. concentrationFractions concentrated by rotary evaporation

Sources & evidence

ORD record
ord-ecd3cf0627354d11878e11b3af598b93
Source dataset
uspto-grants-2015_07
Patent number
US09079906B2

Reaction notes

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