Urea → HCID 178518523, compound

To a heterogeneous mixture of urea (641 mg, 10.67 mmol) and diethylfluoromalonate (1.96 g, 10.67 mmol) in EtOH (11 mL) was added 2.68 M NaOEt in EtOH (7.96 mL, 21.34 mmol). The mixture was heated at reflux for 60 h and then allowed to cool to room temperature. The mixture was filtered and the cake was then dissolved in warm water and the resulting solution was acidified with concentrated HCl to pH 2. The mixture was allowed to cool to room temperature and then cooled in an ice bath before filtering. The cake was washed with water and dried to afford 5-fluoropyrimidine-2,4,6-triol as a slightly off white solid (1.45 g, 93%).

1. temperatureThe mixture was heated
2. temperatureat reflux for 60 h
3. filtrationThe mixture was filtered
4. dissolutionthe cake was then dissolved in warm water
5. temperatureto cool to room temperature
6. temperaturecooled in an ice bath
7. filtrationbefore filtering
8. washThe cake was washed with water
9. customdried

ORD record

ord-bd3defd2b8a84b22909fd2e6c80a749e

Source dataset

uspto-grants-2015_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09079911B2