反应详情

To tert-butyl (6-bromopyridin-3-yl)(phenyl)methylcarbamate (4-e) (3.4 g, 9.4 mmol), diethyl phosphite (1.55 g, 11.27 mmol) and Et3N (1.14 g, 11.27 mmol) in THF was added PdCl2(dppf) (200 mg). The mixture was heated at reflux under nitrogen overnight. The mixture was filtered and the filtrate was concentrated under vacuum. The residue was purified over silica gel (DCM/MeOH=20/1) to provide the product, 4-f (3.4 g, 86%).

1. temperatureThe mixture was heated
2. temperatureat reflux under nitrogen overnight
3. filtrationThe mixture was filtered
4. concentrationthe filtrate was concentrated under vacuum
5. customThe residue was purified over silica gel (DCM/MeOH=20/1)