反应详情

To (S)—N—((S)-(4-bromophenyl)(4-fluorophenyl)methyl)-2-methylpropane-2-sulfinamide, 19-b, (10 g, 0.026 mol), ethyl methylphosphite (5.6 g, 0.052 mol) and Et3N (7.88 g, 0.78 mol) in THF (100 ml) was added PdCl2(dppf) (2.2 g). The mixture was allowed to stir overnight at reflux. The mixture was filtered and the filtrate was concentrated under vacuum. The residue was taken into dichloromethane and washed with brine. The organic layer was concentrated under vacuum and the residue was purified over silica gel (petroleum ether:ethyl acetate=1/1) to provide the product, 19-c, (6.9 g, 68%).

1. temperatureat reflux
2. filtrationThe mixture was filtered
3. concentrationthe filtrate was concentrated under vacuum
4. washwashed with brine
5. concentrationThe organic layer was concentrated under vacuum
6. customthe residue was purified over silica gel (petroleum ether:ethyl acetate=1/1)