Hydrochloric Acid → HCID 86722737, compound

HRID 1525793Notes

Reaction equation

HRID 1525793 reaction equation
[CH2:1]([O:16][C:17]1[CH:18]=[C:19]([CH:24]=[CH:25][CH:26]=1)[C:20]([O:22]C)=[O:21])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15].[OH-].[Na+].Cl.O>O1CCCC1.C(O)C>[CH2:1]([O:16][C:17]1[CH:18]=[C:19]([CH:24]=[CH:25][CH:26]=1)[C:20]([OH:22])=[O:21])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15]

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 86722738HCID 86722738, compound

Product 1

HCID 86722737HCID 86722737, compoundYield 98.8%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 8028TetrahydrofuranSolvent

Conditions

Temperature
70 °C

Procedure

Compound 1 (2.0 g) was dissolved in tetrahydrofuran (9.0 mL) and ethanol (9.0 mL). Thereto, 5 N aqueous sodium hydroxide solution (2.2 mL) was added, followed by stirring at 70° C. for 14 hours. To the reaction solution, 5 N hydrochloric acid (2.2 mL) and water (18 mL) were added and cooled to 40° C. The obtained solid was filtered and dried under reduced pressure to obtain the title compound (1.9 g) having the following physical property values.

Workup

  1. temperaturecooled to 40° C
  2. filtrationThe obtained solid was filtered
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-21ed348bff3a4bae8486d3798aebaf24
Source dataset
uspto-grants-2015_07
Patent number
US09085523B2

Reaction notes

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