Hydrochloric Acid → HCID 117770605, compound

HRID 1526277Notes

Reaction equation

HRID 1526277 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][O:10][C:11]1[CH:12]=[N:13][C:14]([Br:17])=[CH:15][CH:16]=1)(C)(C)C.[ClH:19]>C(O)C.C(OCC)(=O)C>[ClH:19].[ClH:19].[Br:17][C:14]1[N:13]=[CH:12][C:11]([O:10][CH2:9][CH2:8][NH2:7])=[CH:16][CH:15]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 90157373HCID 90157373, compound

Product 1

HCID 117770605HCID 117770605, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of tert-butyl(2-((6-bromopyridin-3-yl)oxy)ethyl)carbamate obtained in Reference Example 4 (1.20 g) in ethanol (25 mL) was added a 4M solution of hydrogen chloride in ethyl acetate (10 mL) at room temperature. The mixture was stirred at room temperature for 3 days, and the solvent was evaporated under reduced pressure. To the residue was added ethanol, the solvent was evaporated under reduced pressure, and the precipitated solid was collected by filtration to give the title compound (1.09 g).

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. additionTo the residue was added ethanol
  3. customthe solvent was evaporated under reduced pressure
  4. filtrationthe precipitated solid was collected by filtration

Sources & evidence

ORD record
ord-b3a858d5a1394a43b1ff9c262ecb0a5a
Source dataset
uspto-grants-2015_07
Patent number
US09085578B2

Reaction notes

Loading…