N-Ethylpiperidine → 24192-95-8

HRID 1526353Notes

Reaction equation

HRID 1526353 reaction equation
Cl[C:2]1[N:7]=[C:6]([Cl:8])[CH:5]=[CH:4][N:3]=1.C([N:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1)C>COCCOC>[Cl:8][C:6]1[CH:5]=[CH:4][N:3]=[C:2]([N:11]2[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)[N:7]=1

Participants

4

Reactant 2

HCID 13007N-EthylpiperidineHCID 775312,4-Dichloropyrimidine

Product 1

HCID 81734624192-95-8

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

A mixture of 2,4-dichloropyrimidine (1.0 g), 1-ethylpiperidine (1.099 mL) and 1,2-dimethoxyethane (10 mL) was refluxed for 6 hr. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (553.1 mg).

Workup

  1. temperaturewas refluxed for 6 hr
  2. customThe solvent was evaporated under reduced pressure
  3. customthe residue was purified by silica gel column chromatography (ethyl acetate/hexane)

Sources & evidence

ORD record
ord-da35447c204d4264a594299c0abe2c46
Source dataset
uspto-grants-2015_07
Patent number
US09085578B2

Reaction notes

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