Ethanol → HCID 117770847, compound

HRID 1526392Notes

Reaction equation

HRID 1526392 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[N:8]1[CH:13]=[CH:12][C:11](OC)=[C:10]([C:16]#[N:17])[C:9]1=[O:18].O.[NH2:20][NH2:21].C(O)C>CN(C)C=O>[NH2:17][C:16]1[C:10]2[C:9](=[O:18])[N:8]([C:7]3[CH:6]=[CH:5][N:4]=[CH:3][C:2]=3[Cl:1])[CH:13]=[CH:12][C:11]=2[NH:21][N:20]=1

Participants

5

Reactant 3

HCID 702EthanolHCID 24654Hydrazine hydrate (1:1)HCID 117770470HCID 117770470, compound

Product 1

HCID 117770847HCID 117770847, compoundYield 85.7%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
60 °C

Procedure

A mixture of 3′-chloro-4-methoxy-2-oxo-2H-[1,4′-bipyridine]-3-carbonitrile obtained in Step C (0.35 g), hydrazine monohydrate (0.17 g), ethanol (10 mL) and N,N-dimethylformamide (10 mL) was stirred at 60° C. for 2 hr. The solvent was evaporated under reduced pressure, to the residue was added isopropyl ether, and the mixture was stirred for 15 min. The precipitate was collected by filtration to give the title compound (0.30 g).

Workup

  1. customThe solvent was evaporated under reduced pressure, to the residue
  2. additionwas added isopropyl ether
  3. stirringthe mixture was stirred for 15 min
  4. filtrationThe precipitate was collected by filtration

Sources & evidence

ORD record
ord-7102f1a93e0f4278a3a22af79f099691
Source dataset
uspto-grants-2015_07
Patent number
US09085578B2

Reaction notes

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