Dimethylformamide dimethyl acetal → HCID 131733171, compound

HRID 1526400Notes

Reaction equation

HRID 1526400 reaction equation
[CH3:1][CH:2]([CH3:12])[C@@H:3]([NH:5][C:6](=[O:11])[CH2:7][C:8](=[O:10])[CH3:9])[CH3:4].CO[CH:15](OC)[N:16]([CH3:18])[CH3:17]>CN(C)C=O>[CH3:15][N:16]([CH:18]=[C:7]([C:8](=[O:10])[CH3:9])[C:6]([NH:5][C@H:3]([CH:2]([CH3:12])[CH3:1])[CH3:4])=[O:11])[CH3:17]

Participants

4

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 29012796HCID 29012796, compound

Product 1

HCID 131733171HCID 131733171, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of N-((2S)-3-methylbutan-2-yl)-3-oxobutanamide obtained in Step A (56.6 g) in N,N-dimethylformamide (220 mL) was added dropwise 1,1-dimethoxy-N,N-dimethylmethanamine (88 mL) over 15 min under ice bath, and the mixture was stirred at room temperature for 20 hr. The solvent was evaporated under reduced pressure to give the title compound (62.7 g).

Workup

  1. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-f9de11f7c06246be8eb9c1630f3fa593
Source dataset
uspto-grants-2015_07
Patent number
US09085578B2

Reaction notes

Loading…