反应详情

A suspension of 3-bromo-5-tert-butylbenzaldehyde (41.5 g, 0.17 mol), malonic acid (21.5 g, 0.20 mol) and ammonium acetate (26.6 g, 0.34 mol) in isopropanol (350 mL) was heated at reflux under nitrogen for 14 h to afford a thick colorless solid. The solid was filtered hot, washed with hot isopropanol (2×100 mL) and dried in vacuo to give the desired racemic product as a colorless solid (37.8 g).

1. temperaturewas heated
2. temperatureat reflux under nitrogen for 14 h
3. customto afford a thick colorless solid
4. filtrationThe solid was filtered hot
5. washwashed with hot isopropanol (2×100 mL)
6. customdried in vacuo