Methyl iodide → 4-Chloro-1-methyl-3-nitro-1,2-dihydropyridin-2-one

To a stirred solution of 4-chloro-3-nitropyridin-2(1H)-one (3.0 g, 17 mmol) in N,N-dimethylformamide (50 mL) was added sodium hydride (60% w/w, 1.0 g, 25.5 mmol) in batches at 0° C. The mixture was stirred at room temperature for 30 minutes. Then iodomethane (2.9 g, 20.4 mmol) was added dropwise to the above solution at room temperature. The resultant solution was stirred at room temperature for 12 hours. Once starting material was consumed, the reaction mixture was quenched with ice water (100 mL) at 0˜10° C., and extracted with ethyl acetate (100 mL*3). The organic phase was washed with brine (100 mL*2), dried over anhydrous sodium sulfate, filtered and concentrated to give a residue. The residue was purified by column chromatography (silica gel, dichloromethane/methanol=10:1) to give 4-chloro-1-methyl-3-nitropyridin-2(1H)-one (3 g, 94%) as a yellow solid. LRMS (M+H+) m/z: calcd 188.0. found 188.

1. customOnce starting material was consumed
2. customthe reaction mixture was quenched with ice water (100 mL) at 0˜10° C.
3. extractionextracted with ethyl acetate (100 mL*3)
4. washThe organic phase was washed with brine (100 mL*2)
5. dry with materialdried over anhydrous sodium sulfate
6. filtrationfiltered
7. concentrationconcentrated
8. customto give a residue
9. customThe residue was purified by column chromatography (silica gel, dichloromethane/methanol=10:1)

ORDレコード

ord-75d71e41bebd41a2867d3ff1cc3a80d9

出典データセット

uspto-grants-2015_07

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US09085583B2