Lithium hydroxide, monohydrate → HCID 86673816, compound

HRID 1527268Notes

Reaction equation

HRID 1527268 reaction equation
C[O:2][C:3](=[O:17])[CH2:4][C:5]1[N:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]2=[C:7]([C:14](=[O:16])[CH3:15])[N:6]=1.O[Li:19].O>C1COCC1.O>[C:14]([C:7]1[N:6]=[C:5]([CH2:4][C:3]([O-:17])=[O:2])[N:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=12)(=[O:16])[CH3:15].[Li+:19]

Participants

5

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 68283887HCID 68283887, compound

Product 1

HCID 86673816HCID 86673816, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a solution of (1-acetyl-imidazo[1,5-a]pyridin-3-yl)-acetic acid methyl ester (1.12 g, 4.82 mmol) in THF (15 mL) and water (7.5 mL) was added LiOH.H2O (202 mg, 4.82 mmol). The reaction was stirred at RT for 5.5 h until completion of the reaction. The mixture was concentrated under reduced pressure and the material thus obtained was used in the next step without further purification: MS (UPLC/MS): 219.2 [M+H]+, 241.2 [M+Na]+, 217.2 [M−H]−; tR (HPLC conditions f): 1.03 min.

Workup

  1. concentrationThe mixture was concentrated under reduced pressure
  2. customthe material thus obtained
  3. customwas used in the next step without further purification
  4. custom1.03 min.

Sources & evidence

ORD record
ord-4f719a47138746469d7ba26284c64fed
Source dataset
uspto-grants-2015_07
Patent number
US09085555B2

Reaction notes

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