反应详情

To a solution of 2-cyclopropyl-4-methyl-5-nitropyridine (201 mg, 0.96 mmol) in MeOH (5 mL) were added 3N aqueous HCl (9.6 mL, 28.8 mmol) and Zn powder (376 mg, 5.75 mmol). The mixture was stirred 18 h at RT. The solution was neutralized with a sat. aq. NaHCO3 solution and extracted with CH2Cl2 (3×). The combined organics were dried (Phase Separator) and concentrated under reduced pressure. MS (LC-MS): 149 [M+H]+, tR (HPLC conditions c): 2.22 min.

1. extractionextracted with CH2Cl2 (3×)
2. customThe combined organics were dried (Phase Separator)
3. concentrationconcentrated under reduced pressure
4. custom2.22 min.