Hydrochloric Acid → HCID 131733206, compound

HRID 1527474Notes

Reaction equation

HRID 1527474 reaction equation
C(OC(=O)[NH:7][CH2:8][C:9]1[CH:14]=[C:13]([C:15]2[N:16]=[N:17][NH:18][N:19]=2)[CH:12]=[C:11]([Cl:20])[C:10]=1[F:21])(C)(C)C.Cl>O1CCOCC1>[ClH:20].[Cl:20][C:11]1[C:10]([F:21])=[C:9]([CH:14]=[C:13]([C:15]2[N:16]=[N:17][NH:18][N:19]=2)[CH:12]=1)[CH2:8][NH2:7]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68283709HCID 68283709, compound

Product 1

HCID 131733206HCID 131733206, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a solution of [3-chloro-2-fluoro-5-(2H-tetrazol-5-yl)-benzyl]-carbamic acid tert-butyl ester (1.06 g, 3.23 mmol) in dioxane (20 mL) was added a 4M HCl solution in dioxane (8.09 mL, 32.3 mmol). The reaction mixture was stirred at RT for 72 h and then freeze-dried overnight to afford the title compound as a white solid. MS (LC/MS): 228.0 [M+H]+; tR (HPLC conditions c): 2.68 min.

Workup

  1. customfreeze-dried overnight

Sources & evidence

ORD record
ord-a7d6857e3e914ef18d321294897b4911
Source dataset
uspto-grants-2015_07
Patent number
US09085555B2

Reaction notes

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