Hydrochloric Acid → 3-Chloro-2-fluoro-5-morpholin-4-ylmethyl-benzylamine

HRID 1527491Notes

Reaction equation

HRID 1527491 reaction equation
C(OC(=O)[NH:7][CH2:8][C:9]1[CH:14]=[C:13]([CH2:15][N:16]2[CH2:21][CH2:20][O:19][CH2:18][CH2:17]2)[CH:12]=[C:11]([Cl:22])[C:10]=1[F:23])(C)(C)C.Cl>O1CCOCC1>[Cl:22][C:11]1[C:10]([F:23])=[C:9]([CH:14]=[C:13]([CH2:15][N:16]2[CH2:21][CH2:20][O:19][CH2:18][CH2:17]2)[CH:12]=1)[CH2:8][NH2:7]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68283950(3-Chloro-2-fluoro-5-morpholin-4-ylmethyl-benzyl)-carbamic acid tert-butyl ester

Product 1

HCID 682840923-Chloro-2-fluoro-5-morpholin-4-ylmethyl-benzylamine

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

was prepared according to Scheme C2 (step D) from (3-chloro-2-fluoro-5-morpholin-4-ylmethyl-benzyl)-carbamic acid tert-butyl ester (231 mg, 0.64 mmol) and 4N HCl in dioxane. MS (LC-MS): 259.0 [M]+.

Workup

  1. customwas prepared

Sources & evidence

ORD record
ord-5b4fe3c7e3ab4fedb02e3c4d825c6965
Source dataset
uspto-grants-2015_07
Patent number
US09085555B2

Reaction notes

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