Hydrochloric Acid → N-(3-Aminomethyl-5-chloro-4-fluoro-benzyl)-N',N'-dimethyl-ethane-1,2-diamine

HRID 1527501Notes

Reaction equation

HRID 1527501 reaction equation
C(OC(=O)[NH:7][CH2:8][C:9]1[CH:14]=[C:13]([CH2:15][N:16]([CH2:18][CH2:19][N:20]([CH3:22])[CH3:21])C)[CH:12]=[C:11]([Cl:23])[C:10]=1[F:24])(C)(C)C.Cl>O1CCOCC1>[NH2:7][CH2:8][C:9]1[CH:14]=[C:13]([CH:12]=[C:11]([Cl:23])[C:10]=1[F:24])[CH2:15][NH:16][CH2:18][CH2:19][N:20]([CH3:22])[CH3:21]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68284327(3-Chloro-5-{[(2-dimethylamino-ethyl)-methyl-amino]-methyl}-2-fluoro-benzyl)-carbamic acid tert-butyl ester

Product 1

HCID 71009335N-(3-Aminomethyl-5-chloro-4-fluoro-benzyl)-N',N'-dimethyl-ethane-1,2-diamine

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

was prepared according to Scheme C2 (step D) from (3-chloro-5-{[(2-dimethylamino-ethyl)-methyl-amino]-methyl}-2-fluoro-benzyl)-carbamic acid tert-butyl ester (165 mg, 0.46 mmol) and 4N HCl in dioxane (3 mL). MS (LC-MS): 260.0 [M]+.

Workup

  1. customwas prepared

Sources & evidence

ORD record
ord-5f55a96bd60a4778bcd17c86c533ba9c
Source dataset
uspto-grants-2015_07
Patent number
US09085555B2

Reaction notes

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