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HRID1527511

反应详情

EQUATION

反应方程式

HRID 1527511 的结构方程式

REACTANTS

反应物

4
结构：C1COCCN1
HCID8083

Morpholine

C4H9NO

结构：CCN(C(C)C)C(C)C
HCID81531

Diisopropylethylamine

C8H19N

结构：CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F
HCID9886157

Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)

C10H15F6N6OP

结构：CC(C)(C)OC(=O)NCc1cc(C(=O)O)cc(Cl)c1F
HCID68283414

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)NCc1cc(C(=O)N2CCOCC2)cc(Cl)c1F
HCID68283707

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

was prepared according to Scheme C3 (step A) from 3-(tert-butoxycarbonylamino-methyl)-5-chloro-4-fluoro-benzoic acid (125 mg, 0.41 mmol), HATU (235 mg, 0.62 mmol), morpholine (43 mg, 0.49 mmol) and DIPEA (0.22 mL, 1.2 mmol) in DMF (2 mL). MS (LC-MS): 317.0 [M−55]+; tR (HPLC conditions c): 4.65 min.

WORKUP

后处理

  1. customwas prepared
  2. custom4.65 min.