Trifluoroacetic acid → HCID 68284627, compound

HRID 1527563Notes

Reaction equation

HRID 1527563 reaction equation
[Cl:1][C:2]1[C:3]([F:42])=[C:4]([CH:39]=[CH:40][CH:41]=1)[CH2:5][NH:6][C:7]([C@@H:9]1[CH2:13][C@:12]([F:15])([CH3:14])[CH2:11][N:10]1[C:16](=[O:38])[CH2:17][N:18]1[C:26]2[C:21](=[CH:22][C:23]([O:27]CC3C=CC=CC=3)=[CH:24][CH:25]=2)[C:20]([C:35](=[O:37])[CH3:36])=[CH:19]1)=[O:8].C(O)(C(F)(F)F)=O.C1(SC)C=CC=CC=1>>[Cl:1][C:2]1[C:3]([F:42])=[C:4]([CH:39]=[CH:40][CH:41]=1)[CH2:5][NH:6][C:7]([C@@H:9]1[CH2:13][C@:12]([F:15])([CH3:14])[CH2:11][N:10]1[C:16](=[O:38])[CH2:17][N:18]1[C:26]2[C:21](=[CH:22][C:23]([OH:27])=[CH:24][CH:25]=2)[C:20]([C:35](=[O:37])[CH3:36])=[CH:19]1)=[O:8]

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 7520ThioanisoleHCID 68283737HCID 68283737, compound

Product 1

HCID 68284627HCID 68284627, compound

Procedure

The title compound was prepared in a similar manner as described above for Example 577 from (2S,4R)-1-[2-(3-acetyl-5-benzyloxy-indol-1-yl)-acetyl]-4-fluoro-4-methyl-pyrrolidine-2-carboxylic acid 3-chloro-2-fluoro-benzylamide (57.0 mg, 0.096 mmol), TFA (3 mL), and thioanisole (0.114 mL, 0.960 mmol). Solid. MS (LC/MS): 504 [M+H]+; tR (HPLC, conditions k): 3.22 min.

Workup

  1. custom3.22 min.

Sources & evidence

ORD record
ord-60f7dcb8f3384d37bbd061e004f0ba0d
Source dataset
uspto-grants-2015_07
Patent number
US09085555B2

Reaction notes

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