Trifluoroacetic acid → HCID 68283434, compound

HRID 1527564Notes

Reaction equation

HRID 1527564 reaction equation
[Cl:1][C:2]1[C:3]([F:41])=[C:4]([CH:38]=[CH:39][CH:40]=1)[CH2:5][NH:6][C:7]([C@@H:9]1[CH2:14][C@@H:13]2[C@@H:11]([CH2:12]2)[N:10]1[C:15](=[O:37])[CH2:16][N:17]1[C:25]2[C:20](=[CH:21][C:22]([O:26]CC3C=CC=CC=3)=[CH:23][CH:24]=2)[C:19]([C:34](=[O:36])[CH3:35])=[CH:18]1)=[O:8].C(O)(C(F)(F)F)=O.C1(SC)C=CC=CC=1>>[Cl:1][C:2]1[C:3]([F:41])=[C:4]([CH:38]=[CH:39][CH:40]=1)[CH2:5][NH:6][C:7]([C@@H:9]1[CH2:14][C@@H:13]2[C@@H:11]([CH2:12]2)[N:10]1[C:15](=[O:37])[CH2:16][N:17]1[C:25]2[C:20](=[CH:21][C:22]([OH:26])=[CH:23][CH:24]=2)[C:19]([C:34](=[O:36])[CH3:35])=[CH:18]1)=[O:8]

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 7520ThioanisoleHCID 68284306HCID 68284306, compound

Product 1

HCID 68283434HCID 68283434, compound

Procedure

The title compound was prepared in a similar manner as described above for Example 577 from (1R,3S,5R)-2-[2-(3-acetyl-5-benzyloxy-indol-1-yl)-acetyl]-2-aza-bicyclo[3.1.0]hexane-3-carboxylic acid 3-chloro-2-fluoro-benzylamide (79.0 mg, 0.138 mmol), TFA (3 mL) and thioanisole (0.163 mL, 1.38 mmol). Solid. MS (LC/MS): 484 [M+H]+; tR (HPLC, conditions k): 3.18 min.

Workup

  1. custom3.18 min.

Sources & evidence

ORD record
ord-49020997dc814cf7ba8f6cbd1fc04f41
Source dataset
uspto-grants-2015_07
Patent number
US09085555B2

Reaction notes

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