Magnesium Stearate → Clonidine

HRID 1527648Notes

Reaction equation

HRID 1527648 reaction equation
[CH:1]1[CH:6]=[C:5]([Cl:7])[C:4]([NH:8][C:9]2[NH:13][CH2:12][CH2:11][N:10]=2)=[C:3]([Cl:14])[CH:2]=1.Cl.OP([O-])([O-])=O.[Ca+2].C([O-])(=O)CCCCCCCCCCCCCCCCC.[Mg+2].C([O-])(=O)CCCCCCCCCCCCCCCCC>>[CH:1]1[CH:6]=[C:5]([Cl:7])[C:4]([NH:8][C:9]2[NH:13][CH2:12][CH2:11][N:10]=2)=[C:3]([Cl:14])[CH:2]=1

Participants

4

Reactant 3

HCID 11177Magnesium StearateHCID 20179Clonidine HydrochlorideHCID 24441Calcium hydrogen phosphate

Product 1

HCID 2803Clonidine

Procedure

Basically 0.1 mg (base equivalent) of clonidine hydrochloride was blended with 13 mg of calcium phosphate dibasic, with 15 mg of microcrystalline cellulose, with 40 mg of hydroxypropyl methyl cellulose, 1 mg of colloidal silica and 0.9 mg of magnesium stearate.

Sources & evidence

ORD record
ord-d5c273cad9c4439f94bde23bc6e97369
Source dataset
uspto-grants-2015_07
Patent number
US09089559B2

Reaction notes

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