HCID 46180046, compound → HCID 46180314, compound

HRID 1527692Notes

Reaction equation

HRID 1527692 reaction equation
[CH3:1][O:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([O:13][CH3:14])=[C:5]([O:15][CH3:16])[C:4]=1/[CH:17]=[C:18](\[CH3:24])/[C:19]([O:21]CC)=[O:20].COC1C2C(=CC=CC=2)C(OC)=CC=1/C=C(\C)/C(O)=O>CCOC(C)=O>[CH3:1][O:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([O:13][CH3:14])=[C:5]([O:15][CH3:16])[C:4]=1/[CH:17]=[C:18](\[CH3:24])/[C:19]([OH:21])=[O:20]

Participants

4

Reactant 2

HCID 46180046HCID 46180046, compoundHCID 46180242(E)-3-(1,4-dimethoxynaphthalen-2-yl)-2-methylpropenoic acid

Product 1

HCID 46180314HCID 46180314, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Compound 99g was prepared from 98g (0.073 g, 0.22 mmol) as described above for 29a to give 0.068 g (0.22 mmol, 100%) of the product as a tan solid following flash chromatography (1:3 EtOAc:hexanes 0.5% AcOH) and recrystallization from Et2O/hexanes.

Workup

  1. customto give

Sources & evidence

ORD record
ord-536db8ccef6346b3aeed7e3d929240f6
Source dataset
uspto-grants-2015_07
Patent number
US09089605B2

Reaction notes

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