Potassium Carbonate → 3-{1-(4-Bromobenzyl)-6-[(1-methyl-1H-pyrazol-3-yl)methoxy]-1H-benzimidazol-2-yl}-2,2-dimethylpropanoic acid

HRID 1527756ノート

反応式

HRID 1527756 の反応式
[Br:1][C:2]1[CH:27]=[CH:26][C:5]([CH2:6][N:7]2[C:11]3[CH:12]=[C:13]([OH:16])[CH:14]=[CH:15][C:10]=3[N:9]=[C:8]2[CH2:17][C:18]([CH3:25])([CH3:24])[C:19]([O:21]CC)=[O:20])=[CH:4][CH:3]=1.Cl[CH2:29][C:30]1[CH:34]=[CH:33][N:32]([CH3:35])[N:31]=1.C([O-])([O-])=O.[K+].[K+].[OH-].[Na+]>CN(C=O)C.C1COCC1.CO>[Br:1][C:2]1[CH:27]=[CH:26][C:5]([CH2:6][N:7]2[C:11]3[CH:12]=[C:13]([O:16][CH2:29][C:30]4[CH:34]=[CH:33][N:32]([CH3:35])[N:31]=4)[CH:14]=[CH:15][C:10]=3[N:9]=[C:8]2[CH2:17][C:18]([CH3:25])([CH3:24])[C:19]([OH:21])=[O:20])=[CH:4][CH:3]=1

参加物

8

反応物 4

HCID 11430Potassium CarbonateHCID 14798Sodium HydroxideHCID 4239233-(Chloromethyl)-1-methyl-1H-pyrazoleHCID 90411063Ethyl 3-(1-(4-bromobenzyl)-6-hydroxy-1H-benzo[d]imidazol-2-yl)-2,2-dimethylpropanoate

生成物 1

HCID 862674493-{1-(4-Bromobenzyl)-6-[(1-methyl-1H-pyrazol-3-yl)methoxy]-1H-benzimidazol-2-yl}-2,2-dimethylpropanoic acid収率 19%

試薬・触媒・溶媒 3

HCID 887Methanol溶媒HCID 6228Dimethylformamide溶媒HCID 8028Tetrahydrofuran溶媒

反応条件

温度
50 °C

実験手順

A mixture of ethyl 3-(1-(4-bromobenzyl)-6-hydroxy-1H-benzo[d]imidazol-2-yl)-2,2-dimethylpropanoate (322 mg, 0.75 mmol), 3-(chloromethyl)-1-methyl-1H-pyrazole (97.5 mg, 0.75 mmol) and K2CO3 (310 mg, 2.25 mmol) in DMF (20 mL) was stirred at 50° Celsius for 18 h. The resulting residue was dissolved in THF (9 mL), MeOH (9 mL) and NaOH (2 mL, 5%). The mixture was stirred at 40° Celsius. After 16 h the reaction was concentrated to dryness and the residue was dissolved in water (30 mL), washed with EtOAc (20 mL). The aqueous layer was separated and acidified to pH ˜6 with HCl (6 N) then extracted with DCM (2×30 mL). The combined organic layers were dried over Na2SO4, filtered, concentrated to dryness and purified by reverse phase HPLC to give the title compound (63 mg, 19%). MS (ESI): mass calcd. for C24H25BrN4O3, 496.11; m/z found, 497.1 [M+H]+. 1H NMR (300 MHz, CD3OD) δ 7.84 (d, J=2.4, 1H), 7.76 (d, J=9.0, 1H), 7.54 (d, J=8.5, 2H), 7.32 (dd, J=9.0, 2.3, 1H), 7.27 (d, J=2.1, 1H), 7.16 (d, J=8.4, 2H), 6.49 (d, J=2.4, 1H), 5.83 (s, 2H), 5.21 (s, 2H), 3.98 (s, 3H), 3.51 (s, 2H), 1.41 (s, 6H).

後処理

  1. stirringThe mixture was stirred at 40° Celsius
  2. concentrationAfter 16 h the reaction was concentrated to dryness
  3. dissolutionthe residue was dissolved in water (30 mL)
  4. washwashed with EtOAc (20 mL)
  5. customThe aqueous layer was separated
  6. extractionthen extracted with DCM (2×30 mL)
  7. dry with materialThe combined organic layers were dried over Na2SO4
  8. filtrationfiltered
  9. concentrationconcentrated to dryness
  10. custompurified by reverse phase HPLC

出典と根拠

ORDレコード
ord-bf18f3b411514425aa46bf3d5ed4f535
出典データセット
uspto-grants-2015_07
特許番号
US09089569B2

反応ノート

読み込み中…