Hydrochloric Acid → HCID 86686552, compound

HRID 1528059Notes

Reaction equation

HRID 1528059 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([N:15]2[CH:19]=[C:18]([F:20])[C:17]([F:21])=[CH:16]2)[CH:12]=[CH:11][C:10]=1[N:22]1[CH:27]=[C:26]([O:28][CH3:29])[C:25](=[O:30])[C:24]([C:31]([O:33]C)=[O:32])=[N:23]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+].C1COCC1.Cl>CO>[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([N:15]2[CH:19]=[C:18]([F:20])[C:17]([F:21])=[CH:16]2)[CH:12]=[CH:11][C:10]=1[N:22]1[CH:27]=[C:26]([O:28][CH3:29])[C:25](=[O:30])[C:24]([C:31]([OH:33])=[O:32])=[N:23]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 86686550HCID 86686550, compound

Product 1

HCID 86686552HCID 86686552, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of methyl 1-[2-(benzyloxy)-4-(3,4-difluoro-1H-pyrrol-1-yl)phenyl]-5-methoxy-4-oxo-1,4-dihydropyridazine-3-carboxylate (4.54 g), 1M aqueous sodium hydroxide solution (15 mL), THF (30 mL) and methanol (30 mL) was stirred at room temperature for 30 min. The reaction mixture was neutralized with 1M hydrochloric acid, and the precipitate was collected by filtration, and washed with water to give the title compound (0.5 THF solvate, 4.70 g).

Workup

  1. filtrationthe precipitate was collected by filtration
  2. washwashed with water

Sources & evidence

ORD record
ord-ace36f4df843405d85ec159f73e36e40
Source dataset
uspto-grants-2015_07
Patent number
US09090586B2

Reaction notes

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