Dimethylformamide dimethyl acetal → HCID 71272472, compound

HRID 1528061Notes

Reaction equation

HRID 1528061 reaction equation
[C:1]([C:4]1[C:9](=[O:10])[C:8]([O:11][CH3:12])=[CH:7][N:6]([C:13]2[CH:18]=[CH:17][C:16]([N:19]3[CH:23]=[C:22]([F:24])[C:21]([F:25])=[CH:20]3)=[CH:15][C:14]=2[O:26][CH2:27][C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[N:5]=1)(=[O:3])[CH3:2].CO[CH:36](OC)[N:37]([CH3:39])[CH3:38]>C(#N)C>[CH2:27]([O:26][C:14]1[CH:15]=[C:16]([N:19]2[CH:23]=[C:22]([F:24])[C:21]([F:25])=[CH:20]2)[CH:17]=[CH:18][C:13]=1[N:6]1[CH:7]=[C:8]([O:11][CH3:12])[C:9](=[O:10])[C:4]([C:1](=[O:3])[CH:2]=[CH:36][N:37]([CH3:39])[CH3:38])=[N:5]1)[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1

Participants

4

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 71272063HCID 71272063, compound

Product 1

HCID 71272472HCID 71272472, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A mixture of 3-acetyl-1-[2-(benzyloxy)-4-(3,4-difluoro-1H-pyrrol-1-yl)phenyl]-5-methoxypyridazin-4(1H)-one (3.70 g), N,N-dimethylformamide dimethyl acetal (40 mL) and acetonitrile (40 mL) was heated under reflux for 6 hr. The reaction mixture was concentrated under reduced pressure, and the residue was crystallized from ethanol to give the title compound (3.85 g).

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 6 hr
  3. concentrationThe reaction mixture was concentrated under reduced pressure
  4. customthe residue was crystallized from ethanol

Sources & evidence

ORD record
ord-33bcf8f794e84d2193ff4166d613094e
Source dataset
uspto-grants-2015_07
Patent number
US09090586B2

Reaction notes

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