反应详情

温度

120 °C

To 1-(5-ethyl-2,4-dihydroxy-phenyl)-2-naphthalen-2-yl-ethanone (c, 0.50 g) was added a mixture of pyridine (2 mL), trimethyl orthoformate (2 mL) and piperidine (2 drops), and the mixture was heated at 120° C. for 12 h. The mixture was cooled to room temperature, diluted with EtOAc (100 mL) then washed with 1 N HCl (100 mL). The organic layer was washed with water and dried. The oil obtained on concentration of the organic layer was crystallized in EtOAc/hexanes to give 6-ethyl-7-hydroxy-3-naphthalen-2-yl-chromen-4-one (d, 0.36 g).

1. temperatureThe mixture was cooled to room temperature
2. washthen washed with 1 N HCl (100 mL)
3. washThe organic layer was washed with water
4. customdried
5. customThe oil obtained on concentration of the organic layer
6. customwas crystallized in EtOAc/hexanes