Lithium Hydroxide → HCID 66578155, compound

HRID 1528699Notes

Reaction equation

HRID 1528699 reaction equation
C([O:3][C:4]([C:6]1([C:9]2[CH:14]=[CH:13][C:12]([C:15]3[CH:20]=[CH:19][C:18]([C:21]4[O:25][N:24]=[C:23]([CH3:26])[C:22]=4[NH:27][C:28](=[O:33])[CH2:29][CH:30]([CH3:32])[CH3:31])=[CH:17][CH:16]=3)=[CH:11][CH:10]=2)[CH2:8][CH2:7]1)=[O:5])C.[OH-].[Li+]>CO.O>[CH3:26][C:23]1[C:22]([NH:27][C:28](=[O:33])[CH2:29][CH:30]([CH3:32])[CH3:31])=[C:21]([C:18]2[CH:19]=[CH:20][C:15]([C:12]3[CH:11]=[CH:10][C:9]([C:6]4([C:4]([OH:5])=[O:3])[CH2:7][CH2:8]4)=[CH:14][CH:13]=3)=[CH:16][CH:17]=2)[O:25][N:24]=1

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 66578386HCID 66578386, compound

Product 1

HCID 66578155HCID 66578155, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Conditions

Temperature
60 °C

Procedure

1-{4′-[3-Methyl-4-(3-methyl-butyrylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid ethyl ester (0.060 g, 0.13 mmol) in MeOH and H2O was treated with lithium hydroxide (0.100 g, 2.4 mmol) and stirred at 60° C. for 1 hour. The mixture was submitted to standard workup to give the title compound.

Sources & evidence

ORD record
ord-91e4f41c982544108b77cf71f84679e6
Source dataset
uspto-grants-2015_07
Patent number
US09090573B2

Reaction notes

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