m-Chloroperbenzoic acid → HCID 66578050, compound

HRID 1528778Notes

Reaction equation

HRID 1528778 reaction equation
ClC1C=CC=C(C(OO)=[O:9])C=1.[CH2:12]([S:19][CH2:20][C:21]1[C:22]([CH3:44])=[N:23][O:24][C:25]=1[C:26]1[CH:31]=[CH:30][C:29]([C:32]2[CH:37]=[CH:36][C:35]([C:38]3([C:41]([OH:43])=[O:42])[CH2:40][CH2:39]3)=[CH:34][CH:33]=2)=[CH:28][CH:27]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>C(Cl)Cl>[CH3:44][C:22]1[C:21]([CH2:20][S:19]([CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[O:9])=[C:25]([C:26]2[CH:31]=[CH:30][C:29]([C:32]3[CH:33]=[CH:34][C:35]([C:38]4([C:41]([OH:43])=[O:42])[CH2:40][CH2:39]4)=[CH:36][CH:37]=3)=[CH:28][CH:27]=2)[O:24][N:23]=1

Participants

4

Reactant 2

HCID 70297m-Chloroperbenzoic acidHCID 66578095HCID 66578095, compound

Product 1

HCID 66578050HCID 66578050, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

m-Chloroperbenzoic acid (0.024 g, 0.11 mmol) was added to a solution of 1-[4′-(4-benzylsulfanylmethyl-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid (0.050 g, 0.11 mmol) in CH2Cl2. After stirring for 15 minutes the mixture was concentrated and the residue was purified by preparative HPLC to give the title compound.

Workup

  1. concentrationwas concentrated
  2. customthe residue was purified by preparative HPLC

Sources & evidence

ORD record
ord-d3da5a78cbfd4747bc958b0d1a83541c
Source dataset
uspto-grants-2015_07
Patent number
US09090573B2

Reaction notes

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