反应详情

温度

50 °C

A glass scintillation vial containing tert-butyl 1-(6-(5-bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-3-yl)pyrazin-2-yl)piperidin-4-ylcarbamate 1e (0.338 g, 0.606 mmol) and HCl, 5-6N in IPA (12 mL, 60.0 mmol) was stirred vigorously at 50° C. for 4 h. The reaction mixture was cooled to RT and the solvent was removed in vacuo. The residue was concentrated to dryness to give a yellow solid that was used in the next step without further purification. MS (ESI, pos. ion) m/z: 373 (M+1).

1. temperatureThe reaction mixture was cooled to RT
2. customthe solvent was removed in vacuo
3. concentrationThe residue was concentrated to dryness
4. customto give a yellow solid that
5. customwas used in the next step without further purification