Diisopropylethylamine → HCID 59708411, compound

HRID 1529508Notes

Reaction equation

HRID 1529508 reaction equation
[Cl:1][C:2]1[N:3]=[C:4](Cl)[C:5]2[S:10][CH2:9][CH2:8][C:6]=2[N:7]=1.C(N(C(C)C)CC)(C)C.[NH2:21][CH:22]1[CH2:27][CH2:26][O:25][CH2:24][CH2:23]1>O1CCOCC1>[Cl:1][C:2]1[N:3]=[C:4]([NH:21][CH:22]2[CH2:27][CH2:26][O:25][CH2:24][CH2:23]2)[C:5]2[S:10][CH2:9][CH2:8][C:6]=2[N:7]=1

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 4192234-AminotetrahydropyranHCID 457899672,4-Dichloro-6,7-dihydrothieno[3,2-d]pyrimidine

Product 1

HCID 59708411HCID 59708411, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
130 °C

Procedure

0.68 g (II) are placed in 6 ml dioxane, then 1.72 ml diisopropylethylamine followed by 0.6 g 4-aminotetrahydropyran are added. The reaction mixture is heated at 130° C. until there is no further reaction and after cooling evaporated down. The product is treated with water in the ultrasound bath, suction filtered and dried. 0.66 g (III-5) are obtained as a solid.

Workup

  1. additionare added
  2. customno further reaction
  3. temperatureafter cooling
  4. customevaporated down
  5. additionThe product is treated with water in the ultrasound bath, suction
  6. filtrationfiltered
  7. customdried
  8. custom0.66 g (III-5) are obtained as a solid

Sources & evidence

ORD record
ord-9e7440501c94461da4af032a12b75941
Source dataset
uspto-grants-2015_07
Patent number
US09090626B2

Reaction notes

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