Hydrazine hydrate (1:1) → HCID 178433742, compound

HRID 1530021Notes

Reaction equation

HRID 1530021 reaction equation
[C:1]([C:5]1[N:6]=[C:7]([C:13]2[C:14]([CH3:22])=[N:15][N:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=23)[S:8][C:9]=1[C:10]([NH2:12])=O)([CH3:4])([CH3:3])[CH3:2].COC(OC)[N:26]([CH3:28])C.O.[NH2:32]N>C(O)(=O)C>[C:1]([C:5]1[N:6]=[C:7]([C:13]2[C:14]([CH3:22])=[N:15][N:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=23)[S:8][C:9]=1[C:10]1[NH:26][CH:28]=[N:32][N:12]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

5

Reactant 3

HCID 24654Hydrazine hydrate (1:1)HCID 78373Dimethylformamide dimethyl acetalHCID 66857406HCID 66857406, compound

Product 1

HCID 178433742HCID 178433742, compoundYield 85%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Using 4-tert-butyl-2-(2-methylpyrazolo[1,5-a]pyridin-3-yl)-1,3-thiazole-5-carboxamide (230 mg, 0.73 mmol), N,N-dimethylformamide dimethyl acetal (25 mL), acetic acid (25 mL) and hydrazine monohydrate (0.5 mL) as starting materials and in the same manner as in Example 13(vi), the title compound (210 mg, 85%) was obtained as a brown solid.

Sources & evidence

ORD record
ord-74c67e6bea944c7c96731d2d78420a76
Source dataset
uspto-grants-2015_07
Patent number
US09090601B2

Reaction notes

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