Dimethylformamide → HCID 68312737, compound

HRID 1530592Notes

Reaction equation

HRID 1530592 reaction equation
[CH:1]([N:4]1[C:8]([C:9]2[N:10]=[C:11]3[C:17]4[CH:18]=[C:19]([CH:22]=[O:23])[N:20]=[CH:21][C:16]=4[O:15][CH2:14][CH2:13][N:12]3[CH:24]=2)=[N:7][CH:6]=[N:5]1)([CH3:3])[CH3:2].CN(C)C=[O:28].OOS([O-])=O.[K+]>>[CH:1]([N:4]1[C:8]([C:9]2[N:10]=[C:11]3[C:17]4[CH:18]=[C:19]([C:22]([OH:28])=[O:23])[N:20]=[CH:21][C:16]=4[O:15][CH2:14][CH2:13][N:12]3[CH:24]=2)=[N:7][CH:6]=[N:5]1)([CH3:3])[CH3:2]

Participants

4

Reactant 3

HCID 6228DimethylformamideHCID 23707502Potassium hydroxy sulfiteHCID 86671470HCID 86671470, compound

Product 1

HCID 68312737HCID 68312737, compound

Procedure

2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-d]pyrido[4,3-f][1,4]oxazepine-10-carbaldehyde (0.250 g, 0.771 mmol) was dissolved in N,N-Dimethylformamide (2 mL, 0.02 mol). Oxone® (0.569 g, 0.925 mmol) was added and the reaction mixture was stirred overnight at room temperature. A light-brown precipitate formed and was collected by filtration. LC-MS analysis verified precipitate as desired product, 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-d]pyrido[4,3-f][1,4]oxazepine-10-carboxylic acid which was carried on without further purification.

Workup

  1. customA light-brown precipitate formed
  2. filtrationwas collected by filtration
  3. customwas carried on without further purification

Sources & evidence

ORD record
ord-3b4ac986c552426b924ab79a636a2ab7
Source dataset
uspto-grants-2015_07
Patent number
US09090628B2

Reaction notes

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