Dimethylformamide → 4-[3-methyl-1-(propan-2-yl)-1H-1,2,4-triazol-5-yl]-9-oxa-3,6-diazatricyclo[8.4.0.02,6]tetradeca1(14),2,4,10,12-pentaene-12-carboxamide

HRID 1530646Notes

Reaction equation

HRID 1530646 reaction equation
Br[C:2]1[CH:3]=[C:4]2[C:13](=[CH:14][CH:15]=1)[C:12]1[N:8]([CH:9]=[C:10]([C:16]3[N:20]([CH:21]([CH3:23])[CH3:22])[N:19]=[C:18]([CH3:24])[N:17]=3)[N:11]=1)[CH2:7][CH2:6][O:5]2.C[Si](C)(C)N[Si](C)(C)C.C[N:35]([CH:37]=[O:38])C>Cl[Pd](Cl)([P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>[CH3:24][C:18]1[N:17]=[C:16]([C:10]2[N:11]=[C:12]3[N:8]([CH:9]=2)[CH2:7][CH2:6][O:5][C:4]2[C:13]3=[CH:14][CH:15]=[C:2]([C:37]([NH2:35])=[O:38])[CH:3]=2)[N:20]([CH:21]([CH3:23])[CH3:22])[N:19]=1

Participants

5

Reactant 3

HCID 6228DimethylformamideHCID 13838HexamethyldisilazaneHCID 582043229-Bromo-2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine

Product 1

HCID 683129074-[3-methyl-1-(propan-2-yl)-1H-1,2,4-triazol-5-yl]-9-oxa-3,6-diazatricyclo[8.4.0.02,6]tetradeca1(14),2,4,10,12-pentaene-12-carboxamideYield 95%

Reagents, catalysts & solvents 1

HCID 178418476HCID 178418476, compoundCatalyst

Conditions

Temperature
80 °C

Procedure

A mixture of 12-bromo-4-[3-methyl-1-(propan-2-yl)-1H-1,2,4-triazol-5-yl]-9-oxa-3,6-diazatricyclo[8.4.0.02,6]tetradeca1(14),2,4,10,12-pentaene (1.0 g, 2.6 mmol), hexamethyldisilazane (3.0 mL, 14 mmol), and Pd(PPh3)2Cl2 (0.09 g, 0.13 mmol) in dry DMF (10 mL) was heated under CO atmosphere at 80° C. overnight. Most of the solvent was removed and water (20 mL) was added. The solid was collected by filtration, washed with water, and dried in vacuo to afford 4-[3-methyl-1-(propan-2-yl)-1H-1,2,4-triazol-5-yl]-9-oxa-3,6-diazatricyclo[8.4.0.02,6]tetradeca1(14),2,4,10,12-pentaene-12-carboxamide (1.3 g, 95% yield) as a gray solid. LCMS (ESI) m/z: 353.3 [M+H+].

Workup

  1. customMost of the solvent was removed
  2. additionwater (20 mL) was added
  3. filtrationThe solid was collected by filtration
  4. washwashed with water
  5. customdried in vacuo

Sources & evidence

ORD record
ord-1585785d590640039242941963dd0d8c
Source dataset
uspto-grants-2015_07
Patent number
US09090628B2

Reaction notes

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