Sodium hydride → HCID 68313075, compound

HRID 1530682Notes

Reaction equation

HRID 1530682 reaction equation
C(OC(N1CCC(C([O:20][C:21]2[CH:43]=[CH:42][C:24]3[C:25]4[N:29]([CH2:30][CH2:31][O:32][C:23]=3[CH:22]=2)[CH:28]=[C:27]([C:33]2[N:34]([CH:39]([CH3:41])[CH3:40])[N:35]=[C:36]([CH3:38])[N:37]=2)[N:26]=4)CC)CC1)=O)C1C=CC=CC=1.[H-].[Na+].[CH2:46]([O:48][C:49](=[O:58])[C:50](Br)([CH3:56])[C:51]([O:53][CH2:54][CH3:55])=[O:52])[CH3:47]>CN(C=O)C>[CH2:46]([O:48][C:49](=[O:58])[C:50]([O:20][C:21]1[CH:43]=[CH:42][C:24]2[C:25]3[N:29]([CH2:30][CH2:31][O:32][C:23]=2[CH:22]=1)[CH:28]=[C:27]([C:33]1[N:34]([CH:39]([CH3:41])[CH3:40])[N:35]=[C:36]([CH3:38])[N:37]=1)[N:26]=3)([CH3:56])[C:51]([O:53][CH2:54][CH3:55])=[O:52])[CH3:47]

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 94944Diethyl bromomethylmalonateHCID 68312705HCID 68312705, compound

Product 1

HCID 68313075HCID 68313075, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a suspension of 2-(2-isopropyl-5-methyl-2H-[1,2,4]triazol-3-yl)-4,5-dihydro-6-oxa-1,3a-diazabenzo[e]azulen-8-ol from Example 4 (100 mg, 0.307 mmol) in DMF (2 mL) was added sodium hydride (12.3 mg, 60% in oil, 0.307 mmol). The mixture was stirred at RT (room temperature) for 15 min, then 2-bromo-2-methylmalonic acid diethyl ester (88 μL, 0.461 mmol) was added. The reaction mixture was stirred at RT for 45 min, and then partitioned between water and EtOAc. The aqueous phase was extracted with EtOAc and the combined organic layers were washed with water, followed by brine, then dried (Na2SO4) and concentrated in vacuo. The resulting residue was purified by column chromatography (Si-PCC, gradient 2-8% MeOH in DCM) affording the title compound as a colourless gum (148 mg, 97%). LCMS (Method B): RT 3.46 min [M+H]+ 498.

Workup

  1. stirringThe reaction mixture was stirred at RT for 45 min
  2. custompartitioned between water and EtOAc
  3. extractionThe aqueous phase was extracted with EtOAc
  4. washthe combined organic layers were washed with water
  5. dry with materialdried (Na2SO4)
  6. concentrationconcentrated in vacuo
  7. customThe resulting residue was purified by column chromatography (Si-PCC, gradient 2-8% MeOH in DCM)

Sources & evidence

ORD record
ord-5d94c13818bc44f6bbab18771df8440b
Source dataset
uspto-grants-2015_07
Patent number
US09090628B2

Reaction notes

Loading…