反应详情

Sodium hydride (144 mg; 6 mmol) was suspended in dimethoxyethane (16 ml) and then in turn, with stirring, there was added 2-(4-ethoxyphenyl)-2-trifluoromethyl-1-propanol (1.25 g; 5.044 mmol), a spatula of sodium iodide and 4-fluoro-3-phenoxybenzyl bromide (1.4 g; 5.04 mmol). After stirring for 5 hours at room temperature, the mixture was added to ice-water, extracted 3 times with ether and the extracts washed with water dried over sodium sulphate and evaporated. After chromatography on silica gel using a mixture of ethyl acetate and hexane, there was obtained 2.06 g of product (=91.1% of theory).

1. stirringAfter stirring for 5 hours at room temperature
2. extractionextracted 3 times with ether
3. washthe extracts washed with water
4. dry with materialdried over sodium sulphate
5. customevaporated
6. additionAfter chromatography on silica gel using a mixture of ethyl acetate and hexane