4-(3,3,3-Trifluoropropyl)phenol → HCID 21252690, compound

HRID 1530799Notes

Reaction equation

HRID 1530799 reaction equation
[H][H].[F:3][C:4]([F:15])([F:14])[CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([OH:13])=[CH:9][CH:8]=1>C(O)(C)C.[Rh]>[F:3][C:4]([F:14])([F:15])[CH2:5][CH2:6][CH:7]1[CH2:12][CH2:11][CH:10]([OH:13])[CH2:9][CH2:8]1

Participants

5

Reactant 2

HCID 134059054-(3,3,3-Trifluoropropyl)phenolHCID 178418361HCID 178418361, compound

Product 1

HCID 21252690HCID 21252690, compound

Reagents, catalysts & solvents 2

HCID 23948RhodiumCatalystHCID 3776IsopropanolSolvent

Procedure

At 50° C. and 150 bar hydrogen pressure, 40.7 g of 4-(3,3,3-trifluoropropyl)phenol in 800 ml of isopropanol were hydrogenated using rhodium on carbon as catalyst for 20 h. The catalyst was filtered off and the reaction solution was concentrated, to give the title product as a colourless solid which was reacted further without any purification.

Workup

  1. customAt 50° C.
  2. customfor 20 h
  3. filtrationThe catalyst was filtered off
  4. concentrationthe reaction solution was concentrated

Sources & evidence

ORD record
ord-7060604328b04fffb52ac74b1780025b
Source dataset
uspto-grants-2001_03
Patent number
US06197729B1

Reaction notes

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