HCID 21252687, compound → HCID 21252718, compound

HRID 1530804Notes

Reaction equation

HRID 1530804 reaction equation
[F:1][CH:2]([F:12])[CH:3]([C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[CH:7][CH:6]=1)[CH3:4]>C(O)(C)C.[Rh]>[F:1][CH:2]([F:12])[CH:3]([CH:5]1[CH2:10][CH2:9][CH:8]([OH:11])[CH2:7][CH2:6]1)[CH3:4]

Participants

4

Reactant 1

HCID 21252687HCID 21252687, compound

Product 1

HCID 21252718HCID 21252718, compound

Reagents, catalysts & solvents 2

HCID 23948RhodiumCatalystHCID 3776IsopropanolSolvent

Procedure

At 50° C. and 150 bar, 19.7 g of 4-(2,2-difluoro-1-methylethyl)phenol in 150 ml of isopropanol were hydrogenated in the presence of rhodium on carbon as catalyst for 20 h. The catalyst was filtered off and the reaction solution was concentrated, giving 16.9 g (83% of theory) of product as a colourless oil which was reacted further without any purification.

Workup

  1. filtrationThe catalyst was filtered off
  2. concentrationthe reaction solution was concentrated
  3. customgiving 16.9 g (83% of theory) of product as a colourless oil which
  4. customwas reacted further without any purification

Sources & evidence

ORD record
ord-90ab2405f973424ebd092afbb01151fb
Source dataset
uspto-grants-2001_03
Patent number
US06197729B1

Reaction notes

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