反应详情

To a solution of 5-amino-indan-2-yl)-carbamic acid tert-butyl ester (12.5 mmol) in methylene chloride (75 mL) is added diisopropylethyl amine (3.3 g, 25 mmol) followed by a solution of 6-methyl-4′-trifluoromethylbiphenyl-2-carboxylic acid chloride in methylene chloride (See Example 14, 12.6 mmol). After stirring 16 h, the reaction mixture is poured into ethyl acetate and washed with 1N HCl, NaHCO3 solution, and brine. The organic layer is dried (MgSO4) and concentrated under reduced pressure to give a solid. Recrystallization from toluene gives {5-[(6-methyl-4′-trifluoromethylbiphenyl-2-carbonyl)-amino]-indan-2-yl}-carbamic acid terf-butyl ester.

1. washwashed with 1N HCl, NaHCO3 solution, and brine
2. dry with materialThe organic layer is dried (MgSO4)
3. concentrationconcentrated under reduced pressure
4. customto give a solid
5. customRecrystallization from toluene