Potassium Carbonate → HCID 57203891, compound

HRID 1531440Notes

Reaction equation

HRID 1531440 reaction equation
[Cl:1][C:2](=[CH:6][C:7]1[CH:12]=[C:11]([C:13]2[C:17]([Cl:18])=[C:16]([O:19][CH:20]([F:22])[F:21])[N:15]([CH3:23])[N:14]=2)[C:10]([F:24])=[CH:9][C:8]=1[Cl:25])[C:3](Cl)=[O:4].C(=O)([O-])[O-].[K+].[K+].Cl.[CH3:33][O:34][NH2:35]>C1(C)C=CC=CC=1.O>[CH3:33][O:34][NH:35][C:3](=[O:4])[C:2]([Cl:1])=[CH:6][C:7]1[CH:12]=[C:11]([C:13]2[C:17]([Cl:18])=[C:16]([O:19][CH:20]([F:21])[F:22])[N:15]([CH3:23])[N:14]=2)[C:10]([F:24])=[CH:9][C:8]=1[Cl:25]

Participants

6

Reactant 3

HCID 11430Potassium CarbonateHCID 521874O-Methylhydroxylamine hydrochlorideHCID 57212797HCID 57212797, compound

Product 1

HCID 57203891HCID 57203891, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolvent2×HCID 1140TolueneSolvent2×

Conditions

Temperature
20 °C

Procedure

A solution of 4.5 g (10 mmol) of 2-chloro-3-(2-chloro-5-(4-chloro-5-difluoromethoxy-1-methyl-1H-pyrazol-3-yl)-4-fluorophenyl)acryloyl chloride in 25 ml of toluene was treated with 25 ml of water, 14.4 g (0.1 mol) of potassium carbonate and 1.7 g (20 mmol) of methoxyamine hydrochloride. After the mixture had been stirred for 16 hours at approximately 20° C., it was heated for a further 2 hours at 40° C. The reaction mixture was subsequently diluted with 200 ml of toluene and 200 ml of water. The solids were then filtered off. The organic phase was dried over magnesium sulfate and finally concentrated. Yield: 3.1 g.

Workup

  1. temperatureit was heated for a further 2 hours at 40° C
  2. filtrationThe solids were then filtered off
  3. dry with materialThe organic phase was dried over magnesium sulfate
  4. concentrationfinally concentrated

Sources & evidence

ORD record
ord-22843fae40884c26a3e4a4657308b141
Source dataset
uspto-grants-2001_03
Patent number
US06197973B1

Reaction notes

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