Potassium Carbonate → HCID 70247069, compound

HRID 1531740Notes

Reaction equation

HRID 1531740 reaction equation
Cl.[CH2:2]([O:4][C:5]([CH2:7][N:8]([S:31]([C:34]1[CH:35]=[CH:36][CH:37]=[C:38]2[C:43]=1[N:42]=[CH:41][CH:40]=[CH:39]2)(=[O:33])=[O:32])[C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[N:15]([CH3:19])[C:14](=[O:20])[C:13]([CH2:21][C:22]1[CH:30]=[CH:29][C:25]([C:26]([NH2:28])=[NH:27])=[CH:24][CH:23]=1)=[N:12]2)=[O:6])[CH3:3].[C:44](=[O:47])([O-])[O-:45].[K+].[K+].C(=O)([O-])OC1C=CC([N+]([O-])=O)=CC=1[CH2:61][CH2:62][S:63]([CH3:66])(=[O:65])=[O:64]>O1CCCC1>[CH2:2]([O:4][C:5]([CH2:7][N:8]([S:31]([C:34]1[CH:35]=[CH:36][CH:37]=[C:38]2[C:43]=1[N:42]=[CH:41][CH:40]=[CH:39]2)(=[O:32])=[O:33])[C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[N:15]([CH3:19])[C:14](=[O:20])[C:13]([CH2:21][C:22]1[CH:23]=[CH:24][C:25]([C:26]([NH2:28])=[N:27][C:44]([O:45][CH2:61][CH2:62][S:63]([CH3:66])(=[O:65])=[O:64])=[O:47])=[CH:29][CH:30]=1)=[N:12]2)=[O:6])[CH3:3]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 21250383HCID 21250383, compoundHCID 66588410HCID 66588410, compound

Product 1

HCID 70247069HCID 70247069, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

0.5 g (0.77 mmol) of 4-{[6-(N-ethoxycarbonylmethyl-quinolin-8-yl-sulphonylamino)-1-methyl-2-oxo-1,2-dihydroquinoxalin-3-yl]-methyl}-benzamidine-hydrochloride, 0.32 g (2.3 mmol) of potassium carbonate and 0.39 g (1.4 mmol) of 2-(methylsulphonyl)-ethyl-4-nitrophenyl carbonate are stirred in 40 ml tetrahydrofuran for 54 hours at ambient temperature. The solvent is distilled off and the residue is taken up in methylene chloride and sodium hydrogen carbonate solution. The combined organic extracts are dried and evaporated down. The residue is chromatographed on aluminium oxide and eluted with methylene chloride+1-5% ethanol.

Workup

  1. distillationThe solvent is distilled off
  2. customThe combined organic extracts are dried
  3. customevaporated down
  4. customThe residue is chromatographed on aluminium oxide
  5. washeluted with methylene chloride+1-5% ethanol

Sources & evidence

ORD record
ord-7137fc57d4f14a23b95e59775d5decf0
Source dataset
uspto-grants-2001_03
Patent number
US06200976B1

Reaction notes

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