Dimethylformamide dimethyl acetal → HCID 57012287, compound

HRID 1531826Notes

Reaction equation

HRID 1531826 reaction equation
[CH3:1][O:2][C:3](=[O:11])[CH2:4][C:5]1[CH:10]=[CH:9][N:8]=[CH:7][CH:6]=1.CO[CH:14](OC)[N:15]([CH3:17])[CH3:16]>CN(C)C=O>[CH3:1][O:2][C:3](=[O:11])[C:4]([C:5]1[CH:6]=[CH:7][N:8]=[CH:9][CH:10]=1)=[CH:14][N:15]([CH3:17])[CH3:16]

Participants

4

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 122482Methyl 4-pyridylacetate

Product 1

HCID 57012287HCID 57012287, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
80 °C

Procedure

Methyl-4-pyridinylacetate (6.3 g) was dissolved in N,N-dimethylformamide (30 cm3) treated with N,N-dimethylformamide dimethyl acetal (15 cm3) and heated at 80° C. for 2 h. The reaction was then cooled and evaporated under high vacuum to afford crude methyl-3-dimethylamino-2-(pyridin-4-yl)propenoate (7.3 g) which was used without further purification.

Workup

  1. temperatureThe reaction was then cooled
  2. customevaporated under high vacuum

Sources & evidence

ORD record
ord-4af8ed625d1f4218934219a91b17e24e
Source dataset
uspto-grants-2001_03
Patent number
US06200982B1

Reaction notes

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