3-[2-Methoxyethoxy]-5-[phenylmethoxy]benzoic acid, methyl ester → Methyl 3-hydroxy-5-(2-methoxyethoxy)benzoate
Reaction equation
[CH3:1][O:2][CH2:3][CH2:4][O:5][C:6]1[CH:7]=[C:8]([CH:13]=[C:14]([O:16]CC2C=CC=CC=2)[CH:15]=1)[C:9]([O:11][CH3:12])=[O:10]>C(OCC)(=O)C.[Pd]>[OH:16][C:14]1[CH:13]=[C:8]([CH:7]=[C:6]([O:5][CH2:4][CH2:3][O:2][CH3:1])[CH:15]=1)[C:9]([O:11][CH3:12])=[O:10]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
The product from step (ii) (2.74 g) was reduced by catalytic hydrogenation at 1 at. for 16 hours in ethyl acetate solution with 10% palladium on charcoal. Yield 1.5 g.
Sources & evidence
- ORD record
- ord-da7f9a3430164230ae3e032e6eee9787
- Source dataset
- uspto-grants-2001_03
- Patent number
- US06200981B1
Reaction notes
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