Toluene → HCID 131722440, compound

HRID 1531937Notes

Reaction equation

HRID 1531937 reaction equation
[CH:1]1[C:11]2[CH:10]=[CH:9][C:8]3[CH:12]=[CH:13][CH:14]=[CH:15][C:7]=3[CH:6]([C:16]3[C:17](=[O:44])[NH:18][C:19](=[O:43])[N:20]([CH2:22][C:23]4[CH:24]=[C:25]([CH2:29][N:30](C(OC(C)(C)C)=O)[CH2:31][C:32]([O:34][CH3:35])=[O:33])[CH:26]=[CH:27][CH:28]=4)[CH:21]=3)[C:5]=2[CH:4]=[CH:3][CH:2]=1.C1(C)C=CC=CC=1>FC(F)(F)C(O)=O.ClCCl>[CH:12]1[C:8]2[CH:9]=[CH:10][C:11]3[CH:1]=[CH:2][CH:3]=[CH:4][C:5]=3[CH:6]([C:16]3[C:17](=[O:44])[NH:18][C:19](=[O:43])[N:20]([CH2:22][C:23]4[CH:24]=[C:25]([CH2:29][NH:30][CH2:31][C:32]([O:34][CH3:35])=[O:33])[CH:26]=[CH:27][CH:28]=4)[CH:21]=3)[C:7]=2[CH:15]=[CH:14][CH:13]=1

Participants

5

Reactant 2

HCID 1140TolueneHCID 131722441HCID 131722441, compound

Product 1

HCID 131722440HCID 131722440, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of the product of step (iii) (1.8 g) in trifluoroacetic acid (5 ml) and dichloromethane (30 ml) was stirred overnight at room temperature. Toluene was added and the mixture was evaporated. The residue was partitioned between ethyl acetate and saturated aqueous sodium bicarbonate. The organic phase was dried (MgSO4) and evaporated.

Workup

  1. customthe mixture was evaporated
  2. customThe residue was partitioned between ethyl acetate and saturated aqueous sodium bicarbonate
  3. dry with materialThe organic phase was dried (MgSO4)
  4. customevaporated

Sources & evidence

ORD record
ord-88249ed5bb544c3d8094dda496286a7f
Source dataset
uspto-grants-2001_03
Patent number
US06200981B1

Reaction notes

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