Hydrochloric Acid → HCID 21250887, compound

HRID 1531945Notes

Reaction equation

HRID 1531945 reaction equation
[CH:1]1[C:11]2[CH:10]=[CH:9][C:8]3[CH:12]=[CH:13][CH:14]=[CH:15][C:7]=3[CH:6]([C:16]3[C:17](=[S:42])[NH:18][C:19](=[O:41])[N:20]([CH2:22][CH2:23][O:24][C:25]4[C:26]([C:37]([O:39]C)=[O:38])=[C:27]([CH:34]=[CH:35][CH:36]=4)[O:28][CH2:29][C:30]([O:32]C)=[O:31])[CH:21]=3)[C:5]=2[CH:4]=[CH:3][CH:2]=1.[OH-].[Na+].Cl>CO.O>[C:30]([CH2:29][O:28][C:27]1[CH:34]=[CH:35][CH:36]=[C:25]([O:24][CH2:23][CH2:22][N:20]2[CH:21]=[C:16]([CH:6]3[C:7]4[CH:15]=[CH:14][CH:13]=[CH:12][C:8]=4[CH:9]=[CH:10][C:11]4[CH:1]=[CH:2][CH:3]=[CH:4][C:5]3=4)[C:17](=[S:42])[NH:18][C:19]2=[O:41])[C:26]=1[C:37]([OH:39])=[O:38])([OH:32])=[O:31]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 131722446HCID 131722446, compound

Product 1

HCID 21250887HCID 21250887, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Conditions

Temperature
60 °C

Procedure

A mixture of the product from step (vi) (0.073 g) and sodium hydroxide (1 g) in methanol (20 ml) and water (20 ml) was heated at 60° C. overnight. The mixture was acidified with 2M HCl and extracted with ethyl acetate. The extract was evaporated and the residue purified by reverse phase chromatography. Yield 0.04 g.

Workup

  1. extractionextracted with ethyl acetate
  2. customThe extract was evaporated
  3. customthe residue purified by reverse phase chromatography

Sources & evidence

ORD record
ord-7a07e72950b34282b47c96599545559f
Source dataset
uspto-grants-2001_03
Patent number
US06200981B1

Reaction notes

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