Methyl iodide → HCID 131722448, compound

HRID 1531947Notes

Reaction equation

HRID 1531947 reaction equation
[CH:1]1[C:11]2[CH:10]=[CH:9][C:8]3[CH:12]=[CH:13][CH:14]=[CH:15][C:7]=3[CH:6]([C:16]3[C:17](=[S:34])[NH:18][C:19](=[O:33])[N:20]([CH2:22][C:23]4[CH:24]=[C:25]([CH:30]=[CH:31][CH:32]=4)[C:26]([O:28][CH3:29])=[O:27])[CH:21]=3)[C:5]=2[CH:4]=[CH:3][CH:2]=1.[C:35](=O)(O)[O-].[Na+].CI>O.CO>[CH:12]1[C:8]2[CH:9]=[CH:10][C:11]3[CH:1]=[CH:2][CH:3]=[CH:4][C:5]=3[CH:6]([C:16]3[C:17]([S:34][CH3:35])=[N:18][C:19](=[O:33])[N:20]([CH2:22][C:23]4[CH:24]=[C:25]([CH:30]=[CH:31][CH:32]=4)[C:26]([O:28][CH3:29])=[O:27])[CH:21]=3)[C:7]=2[CH:15]=[CH:14][CH:13]=1

Participants

6

Reactant 3

HCID 6328Methyl iodideHCID 516892Sodium BicarbonateHCID 131722449HCID 131722449, compound

Product 1

HCID 131722448HCID 131722448, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Conditions

Temperature
40 °C

Procedure

A mixture of the product from example 2 step (iv) (1 g), sodium bicarbonate (0.22 g) and methyl iodide (0.7 ml) in water (4 ml) and methanol (30 ml) was heated at 40° C. for 4 hours. The mixture was concentrated under reduced pressure and partitioned between ethyl acetate and water. The organic phase was dried (MgSO4) and evaporated. Used directly in the next step.

Workup

  1. concentrationThe mixture was concentrated under reduced pressure
  2. custompartitioned between ethyl acetate and water
  3. dry with materialThe organic phase was dried (MgSO4)
  4. customevaporated

Sources & evidence

ORD record
ord-61974cfada374bcab5acb27437ff9bc5
Source dataset
uspto-grants-2001_03
Patent number
US06200981B1

Reaction notes

Loading…