Imidazole → 4-Chloro-2-trifluoroacetyl-6-(tert-butyldimethylsilyloxy)aniline

HRID 153199Notes

Reaction equation

HRID 153199 reaction equation
[F:21][C:22]([F:23])([F:24])[S:25]([O:26][Si:27]([CH3:28])([CH3:29])[C:30]([CH3:31])([CH3:32])[CH3:33])(=[O:34])=[O:35].[NH2:1][c:2]1[c:3]([C:10]([C:11]([F:12])([F:13])[F:14])=[O:15])[cH:4][c:5]([Cl:9])[cH:6][c:7]1[OH:8].[O:36]=[CH:37][N:38]([CH3:39])[CH3:40].[nH:16]1[cH:17][cH:18][n:19][cH:20]1>>[NH2:1][c:2]1[c:3]([C:10]([C:11]([F:12])([F:13])[F:14])=[O:15])[cH:4][c:5]([Cl:9])[cH:6][c:7]1[O:8][Si:27]([CH3:28])([CH3:29])[C:30]([CH3:31])([CH3:32])[CH3:33]

Participants

5

Reactant 4

HCID 795ImidazoleHCID 6228DimethylformamideHCID 123564tert-Butyldimethylsilyl trifluoromethanesulphonateHCID 159230922'-Amino-5'-chloro-3'-hydroxy-2,2,2-trifluoroacetophenone

Product 1

HCID 159230934-Chloro-2-trifluoroacetyl-6-(tert-butyldimethylsilyloxy)aniline

Sources & evidence

ORD record
ord-58d4a62ad2cf47ec8e6918d84e139778
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

Loading…